Quest for Intelligence Genes Churns Out More Dubious Results

by admin 15. October 2014 22:41

 

For more than 20 years, I’ve hammered behavioral genetics, and especially research linking genes to intelligence. Last spring, I proposed a ban on research into race and intelligence. As I explained in a follow-up post, I oppose this research not only because of its potential to exacerbate racism but also because the entire field of behavioral genetics has a horrendous track record, with a long string of sensational claims that turned out to be erroneous.

I wrote that “the methodology of behavioral geneticists is highly susceptible to false positives. Researchers select a group of people who share a trait and then start searching for a gene that occurs not universally and exclusively but simply more often in this group than in a control group. If you look at enough genes, you will almost inevitably find one that meets these criteria simply through chance.”

A new report in the Proceedings of the National Academy of Sciences has bolstered my skepticism. Titled “Common genetic variants associated with cognitive performance identified using the proxy-phenotype method,” the paper was authored by an international consortium of 59 researchers, including such stars as Steven Pinker and Robert Plomin.

The authors compiled data on academic performance and cognitive tests from more than 100,000 subjects and found three genetic markers “significantly associated with cognitive performance after correction for multiple hypothesis testing.”

This all sounds impressive–until you read an excellent analysis of the PNAS paper by Ewen Callaway of Nature. The effects reported in the PNAS are “maddeningly small,” Callaway notes.

He elaborates: “The three variants the researchers identified were each responsible for an average of 0.3 points on an IQ test. (About two-thirds of the population score between 85 and 115.) That means that a person with two copies of each variant would score 1.8 points higher on an intelligence test than a person with none of them. To put those figures in perspective, those variants have about one-twentieth the influence on intelligence as do gene variants linked to other complex traits such as height, says Daniel Benjamin, a social scientist at Cornell University in Ithaca, New York, who co-led the study.”

Kevin Mitchell, a neurogeneticist at Trinity College, Dublin, tells Callaway: “With effects this small, the chances that they represent false positives are vastly increased.”

Some behavioral geneticists are beginning to acknowledge their field’s profound problems. A 2012 editorial in Behavior Genetics stated: “The literature on candidate gene associations is full of reports that have not stood up to rigorous replication. This is the case both for straightforward main effects and for candidate gene-by-environment interactions… As a result, the psychiatric and behavior genetics literature has become confusing and it now seems likely that many of the published findings of the last decade are wrong or misleading and have not contributed to real advances in knowledge.”

I bet the new PNAS paper will turn out to be yet another “wrong or misleading” report. I applaud Ewen Callaway for treating it with the skepticism it deserves. We need more journalists like him.

John Horgan, Scientific American

 

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